Hakan Göker, Ph. D.,


Ankara University, Faculty of Pharmacy
Department of Pharmaceutical Chemistry, Tandogan 06100, Ankara, Turkey
Office:(90)-312-2033013  or  (90)-312-2033068
Fax: (90)-312-2230562
E-mail: goker@ankara.edu.tr
DATE of BIRTH and PLACE : Dec 20, 1958, Merzifon

MARITAL STATUS : Married, two children




ACADEMIC QUALIFICATIONS
:
1980: BS : University of Ankara, Fac. of Pharmacy
1985: Ph.D. in Pharmaceutical Chemistry, Ankara University, Fac. of Pharmacy
1987: Assistant Professor in Ankara University, Fac. of Pharmacy, Dept. of Pharmaceutical Chemistry
1990: Associate Professor in Ankara University, Fac. of Pharmacy, Dept. of Pharmaceutical Chemistry
1996: Professor in Ankara University, Fac. of Pharmacy, Dept. of Pharmaceutical Chemistry

CURRENT STATUS :
Professor in Ankara University, Faculty of Pharmacy, Department of
  Pharmaceutical Chemistry
Director of Central Instrumental Analysis Laboratory of College of Pharmacy (NMR, LC/MS, elementel analyses, etc.)

RESEARCH INTEREST:  Design and synthesis of novel Benzopyran-4-one derivatives as antiaggregan and spasmolytic activities,  
Design and Synthesis of  novel Benzimidazole, Benzoxazin, Benzopyran and Imidazopyridine derivatives  as antibacterial, antifungal and antiparasitic activities,  
Advanced NMR-Spectroscopic Methods in Drug Research,
The detection of illegal compounds in health foods by NMR and LC-MS methods,
NMR analysis of unfractioned heparins (UHF)  and low molecular weights heparins (LMWH).

ACADEMIC CARIER
1981 -       Ankara University,  Pharmacy Faculty
June 1987   Research Scientist,  Ludwigsfahen,  Germany.
June-September 1994  Research Scientist, Tokushima University, Tokushima, Japan.
August 1998 - May 1999  Research Scientist, Georgia State University, Atlanta, U.S.A.
July - September 2000,   Research Scientist, Georgia State University, Atlanta, U.S.A.
July - August 2001, Research Scientist, Georgia State University, Atlanta, U.S.A.

AWARDS:
Novartis  (Pharmaceutical and Medicinal Chemistry, 2007, First winner prize)
Novartis  (Pharmaceutical and Medicinal Chemistry, 2011, Second winner prize)
Bioorganic and Medicinal Chemistry (from Elsevier)  Most cited Paper Award (2005-2008)
Bioorganic and Medicinal Chemistry Letters (from Elsevier)  Most cited Articles to 2003-2008 Award

PUBLICATIONS:
1.
M.Ertan, R.Ertan, H.Göker , U.Pindur., Studies on the Synthesis of Some Flavonoid DerivativesPossessing Spasmolytic Activity V. Arch.Pharm. (Weinheim) , 320, 1132,  1987.

2. R.Ertan, H.Göker, M.Ertan, U.Pindur., Synthesis of New Annulated Flavonoid DerivativesPossessing Spasmolytic Activity VII. Arch.Pharm (Weinheim), 322, 237,  1989
3. H.Göker, R.Ertan., Studies on the Synthesis of Some Biologically Active Flavonoid Derivatives, Die Pharmazie, 45, 734, 1990.
4. H.Göker, R.Ertan, H.Akgün, N.Yulug., Synthesis and Antifungal Activity of Some New Benzimidazole Derivatives, Arch.Pharm (Weinheim) 324, 283, 1991.
5. R.Ertan, H.Göker, M.Ertan, A.Beretz, J.P.Cazenave, M.Haag, R.Anton,Synthesis of Some FlavoneDerivatives : Potent Inhibitors  Human Platelet Aggregation, Eur. J. Med. Chem, 26,735,1991.
6. H.Göker, M.Tunçbilek, G. Leoncini, E.Buzzi, M. Mazzei, Y. Rolland, R. Ertan, Synthesis and Inhibitory Activities on Platelet Aggregation of Some Flavonoid Analogues, Arznm.Forschung ,
      45(1), 2, 150-155,  1995 .

7. H. Göker, C. Kus, U. Abbasoglu, Synthesis of 1,2,5(6)-Trisubstituted Benzimidazoles and Evaluation  of Their Antimicrobial Activities, Arch.Pharm (Weinheim) 328, 425-430 (1995). 
8. H. Göker, G. Ayhan., M. Tunçbilek, R. Ertan., G. Leoncini, R. Garzoglio., M. Mazzei. Synthesis and Antiaggregator Activity of Some New derivatives of 4H-1-benzopyran-4-one, Eur J Med
    Chem
, 30, 561-567
, 1995.
9. H. Göker, S. Ölgen, R. Ertan, H. Akgün, S. Özbey, E. Kendi, G. Topçu. Synthesis of Some New Benzimidazole-5(6)-carboxylic Acids, J. Hetereocyclic Chem. 32, 1767-1773,  1995.
10.
H. Göker, E. Tebrizli, U. Abbasoglu. Synthesis of 1,2-disubstituted Benzimidazole-5(6)-carboxamides and Evaluation of Their Antimicrobial Activity, Farmaco, 51, 53-58, 1996.

11.
C. Kus, H. Göker, G. Ayhan, R. Ertan, N. Altanlar, A. Akin. Synthesis and Antimicrobial Activity of Some New Piperidinylbenzimidazoles, Farmaco, 51, 6, 413-417, 1996.

12.
M. Tuncbilek, H. Goker, R. Ertan, R. Eryigit, E. Kendi, N, Altanlar. Synthesis and Antimicrobial Activity of Some New Anilino Benzimidazoles, Arch. Pharm. Pharm. Med. Chem., 330,
      372-376, 1997.

13. S. Ozbey, E. Kendi, H. Goker, R. Ertan. {2-(2-Ethoxycarbonyl)-1,4-benzodioxan-7-yl}-4H-1-benzopyran-4-one. Acta Crystallogr. C53, 1981-1983, 1997.
14. E. Kendi, S. Ozbey, M. Tuncbilek, H. Goker . 1-Benzyl-2-(2,6-dichloro-1-anilinomethyl)-1H-benzimidazole. Acta Crystallogr. C54,  854-856 ,1998.
15.
H. Goker, M. Tuncbilek, G. Ayhan, N. Altanlar. Synthesis of Some New Benzimidazole Carboxamides and Evaluation of Their Antimicrobial Activity. Farmaco, 53, 415-420,  1998

16
. S.Ozbay, E. Kendi, H.Goker, M. Tuncbilek. The structure of 1-(p-fluorophenylmethyl)-2-(4-methyl-1-piperazinyl)-1H-benzimidazole hydrogen fumarate. J.Chem. Crystallogr.,                               
       28 (6),  461-464,
1998.   
17
. E.Kendi, S.Ozbay, H.Goker. 2,5-Dichloro-1-(p-chlorobenzyl)-1H-benzimidazole. Acta Crystallogr.C55,  243-245, 1999.

18
. M.M. Candan, E. Kendi and H. Göker 4-Chloro-N-(p-fluorobenzyl)-2-nitroaniline. Acta Crystallogr.C55,  825, 1999.

19
. H. Göker, G. A.Kilcigil,  M.  Tuncbilek,   C. Kus,  R. Ertan,  E. Kendi,  S. Özbey, M. Fort, C. Garcia,and A. J. Farré. Synthesis  and Antihistaminic H1-Activity of 1,2,5(6)-Trisubstituted           
       Benzimidazoles. 
Heterocycles,  51(11), 2561-2573, 1999.
20. G. A.Kilcigil,  M.  Tuncbilek, N. Altanlar, H. Göker, Synthesis and antimicrobial activity of some new benzimidazolecarboxylates and carboxamides. Farmaco, 54, 562-565, 1999.
21. S. Özcan, E. Kendi, M. Tunçbilek, H. GökerMethyl -(4-chlorobenzyl)-2-(4-methylpiperazin-1-yl)-1H-benzimidazole-5-carboxylate hemihydrate Acta Cryst. C56, 459-460, 2000.
22.  S. Özden,  A.M. Öztürk, H. Göker, N. Altanlar, Synthesis and Antimicrobial Activity of Some New 4-Hydroxy-2H-1,4-benzoxazin-3(4H)-ones.  Farmaco 55(11-12), 715-718, 2000.
23. H. Göker , S. Süzen, C. Kus, D.W. Boykin .  Synthesis of New 2-aryl-4H- 4-oxo-1-Benzopyran  oxime Ethers. Hetereocyclic Communications  6, 385-390, 2000.
24. H Göker, M. Tunçbilek, S. Süzen, C. Kus, N. Altanlar,  Synthesis and Antimicrobial Activity of  Some New 2-Phenyl-N-substituted Carboxamido-1H-benzimidazole Derivatives, Arch. Pharm.
       Pharm.
Med. Chem 334, 148-152 , 2001.
25. S. Özbey, C. Kus, H.Göker , Crystal structure of 1-Cyclopropyl-2-ethyl-5-fluoro-6-(4-methyl-piperazin -1-yl)-1H-benzimidazole,   Analytical Sciences, 17(8), 1019-1020, 2001 .
26. C. Kus,  H.Göker ,  N. Altanlar, Synthesis and Antimicrobial Activities of 5-Fluoro-1,2,6-Trisubstituted  Benzimidazole Carboxamide and Acetamide DerivativesArch. Pharm. Pharm. Med.
      Chem
,  334, 361-365
2001.
27.  D.W. Boykin, H.Göker ,  Ring Cleavage of   bis-cyanosubstituted benzimidazoles by DIBAL,  Hetereocyclic Communications, 7, 529-534, 2001.
28H. Göker, C. Kus, D.W. Boykin, S. Yildiz, N. Altanlar,  Synthesis of some new 2-substituted-phenyl-1H- benzimidazole-5-carbonitriles and their potent activity against Candida species,
       Biorg.  Med. Chem. 10, 2589-2596, 2002.
29. C. Kus, H Göker,  D.W. Boykin,  Synthesis of Some New N-Isopropylamidinobenzimidazoles as potential topoisomerase inhibitors,   Hetereocyclic Communications. 8, 215-220,  2002.
30. S. Özbey, F.B. Kaynak, C. Kus, H. Göker, 2-(2,4-Dichlorophenyl)-5-fluoro-6-morpholin-4-yl-1H-benzimidazole monohydrate, Acta Cyrst. E 58, o1062-o1064, 2002.
31. M.D.Givens, C.C.Dykstra, K.V.Brock, D.A.Stringfellow, A.Kumar,  C.E.Stephens,  H. Göker,  D.W.Boykin,  Detection of inhibition Bovine Viral Diarrhea Virus by Aromatic Cationic Molecules,
      Antimicrobial Agents and Chemotherapy, 47(7), 2223-2230, 2003.
32. C.Kazak, H.Göker and S. Ide   2-Acetylphenyl 5-methylthiophene-2-carboxylate  Acta Cryst.2003. E59, o1362-o1363.
33. C. Kazak, V. Yilmaz, H. Göker, C. Kus 1-n-Butyl-2-(4’-Fluorophenyl)-1H-benzimidazole-6-carbonitrile,   Acta Cryst. 2004. E60, m819-m821.
34. S. Özden., H. Karatas., S. Yildiz., H. GokerSynthesis and Potent Antimicrobial Activity of  Some Novel 4-(5,6-Dichloro-1H-benzimidazole-2-yl)-N-substituted benzamidesArch. Pharm.
          Pharm. Med. Chem. 2004, 337, 556-562.  
35. B. Arslan, C. Kazak, H. Göker2,6-Dimethyl-4H-1-benzopyran-4-one, Acta Cryst.,  2004.  E60, o2238-o2240.

36. S. Özbey, F.B. Kaynak., H. Göker, C. Kus. Synthesis and crystal structure elucidation of  1- (4-fluorobenzyl)-2-(4-cyanophenyl)-1H-benzimidazole-5-carbonitrile, J. Chem. Cryst. 34 (12),
      2004.
37. H. Göker.,  D. Boykin., S. Yildiz.  Synthesis and Potent Antimicrobial activity of Some Novel  2-Phenyl  or  Methyl-4H-1-Benzopyran-4-ones carrying  amidinobenzimidazoles,  Bioorg. Med.  
      Chem , 
13, 2005, 1707-1714.
38. S. Özden., D. Atabey,  S.Yildiz, H. GökerSynthesis and Potent Antimicrobial activity of Some Novel  Methyl or Ethyl 1H-Benzimidazole-5-carboxylates derivatives carrying amide or amidine
       groups
,   Bioorg. Med. Chem. 13, 2005, 1587-1597.
39. H. Göker ,  S. Ozden,  S. Yildiz,  D. Boykin,   Synthesis and Potent Antibacterial Activity against MRSA of Some Novel  1,2-Disubstituted-1H-Benzimidazole-N-alkylated-5-carboxamidines,
     
Eur. J. Med. Chem , 40, 
2005,  1062-1069.
4
0. H. Göker,  M. Alp,S.Yildiz, Synthesis & Potent Antimicrobial Activity of Some Novel N-(Alkyl)-2-Phenyl-1H-Benzimidazole-5-carboxamidines, Molecules, 2005,10,1377-1386.
41. Z. Ates-Alagöz,  M. Alp, C. Kus,  S. Yildiz, E. Buyukbingöl,
H. Göker,   Synthesis and Potent Antimicrobial  Activities of Some Novel Retinoidal Monocationic Benzimidazoles, Arch. der.
      Pharm.
2006, 339, 74-80.
42. C. Kazak, V.T. Yilmaz,
H. Göker, C. Kus, Synthesis and molecular structures of 1-n-butyl-2-(3'-chlorophenyl)-1H-benzimidazole-5-carbonitrile hemihydrate and 1-n-butyl-2-(3',4'-dimethoxy
       phenyl)-1H-benzimidazole-5-carbonitrile, Cryst. Res. Technol. 2006, 41, 528-532.

43. Ö.Ö.Güven, T. Erdogan, H.Göker, S.Yildiz, Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers,  Bioorg. Med. Chem. Lett. 2007,17,
      2233-2236. 
44. Ö.Ö.Güven, T. Erdogan, H. Göker, S.Yildiz, Synthesis and antimicrobial activity of some novel Some Novel Furyl and benzimidazole substituted  benzyl ethers, J.   Heterocyclic 
      Chem.,   2007, 44,  731-734.
45. S. Ozden, D. Atabey, S. Yildiz, H. Göker, Synthesis, Potent anti-Staphylococcal Activity and QSARs of Some  Novel 2-Anilinobenzazoles, Eur. J. Med. Chem. 2008, 43, 1390-1402.
46. M. Alp, H. Göker, R. Brun, S. Yildiz,  Synthesis and antiparasitic and antifungal evaluation of 2'-Arylsubstituted-1H,1'H- [2,5']bisbenzimidazolyl-5-carboxamidines, Eur. J. Med. Chem.,2009,
      44, 2002-2008.
47.  H. Göker, M. Alp, Z. Ates-Alagöz, S.Yildiz, Synthesis and Potent Antifungal Activity against Candida species of Some Novel 1H-benzimidazoles,  J. Hetereocyclic Chem. 2009, 46,936-948.
48.  M.O. Püsküllü, S. Yıldız, H. GökerSynthesis and Antistaphylococcal Activity of N-substituted-1H-benzimidazole-sulphonamidesArchiv der Pharmazie, 2010,343,31-39.
49.  H. Göker, M. Coşkun, M. Alp,  Isolation and identification of a new acetildenafil analogue used to adulterate a dietary supplement: dimethylacetildenafil, Turkisch J.chem. , 2010, 34,
       157-164.
50.  S. Özden, F. Usta, N. Altanlar, H. Göker, Synthesis of Some New 1H-Benzimidazole-2-carboxamido derivatives and their antimicrobial activitiy, J.   Heterocyclic  Chem., . 2011, 48,
       1317-1322.
51.  H. Göker, M. Coşkun. G:Ayhan-Kilcigil,  (Book Chapter) Chromatography and its applications  Section 3:  Chromatographic seperation of Sildenafil and Yohimbine Analogues Illegally
       Added  in Herbal Supplements,
2012 , 51-68  (Intech Press)
52.  H. Karataş, M. Alp, S.Yildiz, H. Göker, Synthesis and Potent in vitro activity of Novel 1H-Benzimidazoles as anti-MRSA agents.  Chem Biol Drug Des 2012; 80: 237–244.
53.  H. Göker, C.Karaaslan, S. Yildiz, Synthesis, Potent Antifungal and Antistaphylococcal Activities of Some New 2-Anilinobenzimidazoles,  Z. Naturforsch. 2012; 67c, 486 − 494..
54.  M. Alp, M. Coskun, H. Göker,   Isolation and identification of a new Sildenafil analogue adulterated in Energy Drink : Propoxyphenyl Sildenafil  J. Pharm. & Biomed. Anal. 2013, 72, 155-158.